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KMID : 1134819980270050987
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Journal of the Korean Society of Food Science and Nutrition
1998 Volume.27 No. 5 p.987 ~ p.992
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Cytotoxicity of Ligularia fischeri Extracts
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Ham Seung-Shi
Lee Sang-Young
Oh Deog-Hwan
Jung Seung-Won
Kim Sang-Heon
Chung Cha-Kwon
Kang Il-Jun
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Abstract
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This study was investigated to observe the cytotoxicity effect of Ligularia fischeri extracts against cancer cell lines including human lung carcinoma(A549), human cervix epitheloid carcinoma(HeLa) and human hepatoceliular carcinoma(HepG2) using SRB(sulforhodamine B) method. The ethanol and methanol extracts of 1㎍/μl showed approximately 79.2% and 86.4% cytotoxicity effects on HepG2 cell line and the ethyl acetate fraction fractionated from ethanol extracts showed the strongest cytotoxicity effect with 94% inhibition. The inhibitory effect of ethanol extract on HeLa cell line was somewhat low with 50~56% inhibition, but ethyl acetate fraction showed higher cytotoxicity effect with 91% and 91.9% inhibition on the HeLa and A549 cell line. On the contrary, the ethanol and methanol extracts showed the lower inhibition effects on the normal liver cell, WRL68, compared to human cancer cell lines.
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KEYWORD
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Ligularia fischeri, cytotoxicity, SRB, HepG2, HeLa, A549
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